Furin Cleavage Site Is the ‘Smoking Gun’
As mentioned, furin can also cut or cleave the S2 spike protein subunit. Furin is a protein coding gene that activates certain proteins by snipping off specific sections. As explained by Martenson, contrary to other protein-cutting enzymes, furin is very specific about the locations it cuts. What’s more, when arginine is present in the second or third place of the protein sequence, then the efficiency of the cleavage is magnified.
This, he says, is “the smoking gun” that proves SARS-CoV-2 was created in a lab. An excellent, well-written article7 in Medium also addresses this finding and explains why furin cleavage sites are so important for determining whether SARS-CoV-2 is natural or not.
In “Furin, a Potential Therapeutic Target for COVID-19,”8,9 Chinese researchers report that CoV-2 is the only coronavirus with a furin cleavage site. Not even distant relatives of CoV-2 have it, and the coronaviruses that do have it share only 40% of CoV-2’s genome. As reported in this paper:
“It was found that all Spike with a SARS-CoV-2 Spike sequence homology greater than 40% did not have a furin cleavage site … including Bat-CoVRaTG13 and SARS-CoV (with sequence identity as 97.4% and 78.6%, respectively).
The furin cleavage site ‘RRAR’ in SARS-CoV-2 is unique in its family, rendering by its unique insert of ‘PRRA.’ The furin cleavage site of SARS-CoV-2 is unlikely to have evolved from MERS, HCoV-HKU1, and so on.
From the currently available sequences in databases, it is difficult for us to find the source. Perhaps there are still many evolutionary intermediate sequences waiting to be discovered.”
Mutation Cannot Explain Furin Site in SARS-CoV-2
According to these researchers, the furin cleavage site present in SARS-CoV-2 “is unique in its family” and “is unlikely to have evolved.” In other words, the virus must have been modified somewhere along the way to give it a furin cleavage site, as there’s no apparent source for this virus.
Put another way, there’s no coronavirus out there that is similar enough that SARS-CoV-2 might have evolved or mutated from it.
Martenson does an excellent job of explaining this in his video, so I strongly recommend watching it. Yuri Deigin also does this in his Medium article,11 so if you prefer reading, you can review much of the same data there.
Importantly, both reveal how virologists claiming SARS-CoV-2 is a natural bat coronavirus that jumped to pangolin and then to humans are simply wrong, and the genetic sequence proves it. The furin cleavage site PRRA found in SARS-CoV-2 is NOT found in either bats or pangolins, so it could not have mutated through these animals.
The fact that this furin cleavage site is present in SARS-CoV-2 is evidence that it has been inserted (opposed to mutated), and Martenson provides an easy to understand illustration of the difference between a mutation and an insert in his video. It is extremely unlikely that 12 new nucleotide base pairs would all of a sudden emerge from where there was nothing before.
What About the Studies Saying It’s Natural?
Two studies heavily cited by mainstream media as evidence SARS-CoV-2 is a natural mutation that jumped from animal to human include a February 3, 2020, Nature paper,12 which claims SARS-CoV-2 is a coronavirus of bat origin that then jumped species. However, one of the authors of this paper, Shi Zhengli, was involved in the weaponization of the SARS virus, and therefore has reason to try to cover up any link to such research.
A second paper,13 published in Nature Medicine, March 17, 2020, offers “a perspective on the notable features of the SARS-CoV-2 genome,” and discusses “scenarios by which they could have arisen.” According to this paper, “Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.”
However, even though they acknowledge SARS-CoV-2 has a polybasic cleavage site (PRRA) that does not exist elsewhere, they fail to explain how these 12 base pairs could have magically been inserted naturally. As noted by Martenson, “whole inserts are not part of the mutation pathway.”
Scientific Community Has Reason to Hide Origin
He goes on to cite several studies showing how scientists around the world have been working on inserting cleavage sites to make coronaviruses more virulent. Clearly, we have the capability to create SARS-CoV-2, and scientists around the world have engaged in such research for many years.
Martenson calls out leading virologist Michael Osterholm who, in a March 10, 2020, interview with Joe Rogan, stated that “we could not have crafted a virus like this to do what it’s doing; I mean we don’t have the creative imagination or the skill set.”
Really? Published research shows we clearly have the technology, know-how and “creative imagination” to create SARS-CoV-2, and Osterholm simply cannot be ignorant of that fact.
Another source you may want to look over is the Project Evidence webpage,14 which lists more information pointing toward a lab-created SARS-CoV-2 than I could possibly cover here. A summary of the evidence can be found toward the bottom of the page under “Conclusion.”
Naturally, there must be people in the scientific community who would now want to cover up any link to such research. Would you want to be responsible for creating, funding or having any association whatsoever with a virus responsible for a pandemic that has killed people, destroyed the world economy and put people out of work around the globe?
Would you want to be found guilty of violating the Biological Weapons Anti-Terrorism Act of 1989, the punishment for which goes up to and includes life in prison? The Biological Weapons Anti-Terrorism Act of 1989 states:15
“Whoever knowingly develops, produces, stockpiles, transfers, acquires, retains, or possesses any biological agent, toxin, or delivery system for use as a weapon, or knowingly assists a foreign state or any organization to do so, shall be fined under this title or imprisoned for life or any term of years, or both. There is extraterritorial Federal jurisdiction over an offense under this section committed by or against a national of the United States.”
The National Institutes of Health have in recent years funded dangerous gain-of-function research on bat coronaviruses at the biosafety level 4 (BSL4) laboratory in Wuhan, China.
Gain of function research refers to research in which pathogenicity or transmissibility of pathogens is enhanced to make a pathogen more dangerous to humans.
To gain entry into a cell, the virus must first bind to an ACE2 or CD147 receptor. Next, the S2 spike protein subunit must be proteolytically cleaved. Without this protein cleavage, the virus would be unable to enter.
There are several enzymes that cleave spike proteins, including plasmin, which also degrades fibrin. When a blood clot is dissolved, a byproduct called D-dimer is created, and many patients with serious COVID-19 infection have elevated D-dimer, which is indicative of blood clots.
Another protein cleaver is furin, and the presence of a furin cleavage site on SARS-CoV-2 is “the smoking gun” that proves SARS-CoV-2 was lab-created.